Nanocrystal (Nanoparticles) Drug Delivery in Oncology

Nanocrystal (Nanoparticles) Drug Delivery in Oncology Introduction The aim of this literature review is to expand the boundaries of our knowledge by exploring some relevant literature related to the role of nano-particle in cancer treatment and toxicology. In this paper, the author will discuss the importance of nanocrystals in treating and managing cancers. For this, the author will refer to three different scholarly articles. Heidel Davis, (2011) accentuated that the treatment of cancer is complicated by the exact nature of the cancer cells, the tissue they originate from, and the tissue or tissues they hibernate and colonize in [1]. Many cancers, such as those affecting the colon or liver, remain tucked away in the darker recesses of the body, where they are challenging to detect and even more challenging to treat. Other cancers, such as melanoma or retinoblastoma, are at or near the surface of the body, and thus are more accessible to observation and treatment. All cancer therapies try to target characteristics that are peculiar to cancer cells so as not to damage normal cells. This could be a mutated protein, a peculiar behaviour pattern, such as an increased rate of cell division, or an elevated demand for oxygen to support high metabolic activity by the cancer cells [2]. Discussion Analysis Over 8,767 Australians were expected to die of cancer in 2020 [3]. Over 12 million new cases worldwide were diagnosed in 2007. Sixty percent of cancer cases occur in developing countries. Cancer is on the rise in low- and middle-income countries, cancer is the number one cause of death in China. According to Phan et al., (2009), chemically attached nanocrystals to a viral envelope allowed the scientists to eradicate cancer cells using laser radiation [4]. Binding nanoparticles to an antibody specific for cancer cells can make easier the detection of advanced stage cancer cells. According to Colin, (2008), the ability to quantitatively and noninvasively detect targeted nanoparticles in vivo could provide a promising cancer diagnostic tool. Using nanoparticle to heat up tumors is a main focus in therapeutic oncology applications of nanoscale sciences and technologies [5]. Nanosized Cancer drug Nanocrystal helps in the advancement of creative chemotherapeutic medications particularly in the territory of harmful deteriorating treatment or solution for neurological issue or cancerous growth. It delivers nanosized medications that are just marginally bigger in size than proteins and are subsequently little to such a degree as to move crosswise over ion-control channels(e.g., the blood–brain barriers), scattered all through the entire body including entering the focal sensory system, the vasculature and enter cells specifically [6]. Nanosized pharmaceuticals, due to their greater surface territory and organic undertaking likewise allow lower centralizations of pharmaceuticals to be utilized; accordingly diminish the potential danger of unfavorable responses [7]. The propelled outside area of nanosized pharmaceuticals might likewise help to upgrade dissolvability and support rate of disintegration, in this manner increase oral bioavailability and allow all the more quick onset of remedial activity [8]. A showing of this future is the adaptation of naproxen that have been used to support the expand time in the blood of the patients to empower a great deal more quick issue and help than the acknowledged presentation of naproxen for their cancer treatment [9]. Nano consignment schemes for therapeutics and toxicology Numerous advances have been created to utilize nanoparticles as a part of the treatment regimen of biomedical imaging, toxicological analysis and pharmaceutical conveyance. Applications for these plans will supply materials for controlled medication committal by directing bearers to a particular area with attractive fields or fluorescence biological markers. The transporter will then be initiated on interest in a limited area. The anticipated and extended length of activity in this way help to abatement hindrance of basic redosing, advance patient consistence and keep away from the side effects that so regularly result from intense medications [10]. Use of Nanocrystal in Oncology The interstitial heating using nanoparticles was feasible in patients with cancer with local recurrence and had been previously irradiated. The treatment related toxicity was moderate and the quality of life affected only temporarily. The limiting factors of this technique at present are discomfort caused by high magnetic field strengths and suboptimal intratumoral distribution. Moreover, deposits in the prostates nanoparticles are very durable. At present there is no magnetic imaging and chemotherapy available or neither for direct injection of fluid under visual control real-time nor for a reliable picture of the tumor within the cancer cells. Therefore, the selective ablation of cancer separating normal tissue is not possible at this time, but may become an interesting future with improved diagnostic techniques image subject. Until our heating method is more refined and can be safely applied forces higher photo thermal therapy to achieve higher performance alone, this treatment modality is being evaluated in combination with radiation in patients with localized cancer. Quantum spots, one of the most well revised, are nanocrystals that fluoresce in distinct hues depending on their dimensions (e.g., Cadmium selenide) [11;12]. In the event that the target molecule is an early marker of cancerous detection, discovery of that molecule may show a higher inclination for illness. An illustration is to utilize nanoparticles to join to blood clumps and to help make clusters more clear by ultrasound [13]. Nanoshells, an alternate nanodelivery plan that is made out of copolymers, are used in mix with precise wavelengths of lights and hotness mastery for harmful ailment treatment. These nanodevices can be tuned precisely to drench up or scramble infrared beams. At the point when encased in with gold, they can adjust these types of light into high temperature and either issues the pharmaceutical into the encompassing tissue or specifically blazed/murder tumor units that is tie to these nanoshells [14]. Likewise, attractive fields could be used to center pharmaceutical particles at the tumor area and balancing the territories would discharge the pharmaceutical from the external layer to strike tumor units. Chemotherapeutic Drugs and Cancer Diagnosis Infusion of genetic characteristics into nanocapsules is being tried out. One of the quality being enquired is the tumor necrosis factor, a protein that is fatal to cancer cells as well as besides to wholesome units when infused in substantial measurements [15]. To sidestep impedance to ordinary tissue, the nanocapsule is covered with sensors that objective just on tumor cells. A persevering would then be uncovered to low-dose radiation or medications that launch the quality to make putrefaction part. Other nanodrug bearers, for example, quality firearm with gold particles, fullerenes (made completely out of carbon, as an empty circle (C60 Bucky balls or chamber (nanotubes) and dendrimers (round polymeric molecules) are likewise being inspected. An alternate mean of pharmaceutical conveyance is to settle pharmaceutical with nanoparticles, for instance albumin proteins. It uses the natural carrier albumin rather than synthetic solvents to consign paclitaxel and furthermore for protected management of high paclitaxel doses without premedication, producing in important antitumour undertaking in patients with metastatic breast cancerous disease. Nanodelivery schemes for gene therapy Nanomedical research could outcome in an array of new medical apparatuss. Interesting study projects include use of nano-electromechanical apparatus or nanowire field-effect transistor to detect insect baculovirus and lone influenza viruses respectively were undertook. It is wanted that development of these nanodevices can help doctor to find the difficulty areas in the body more precisely (Lam et al., 2004, p. 5). Other study works engage the use of biochips and microfluidic devices to computer display tissues for genetic dissimilarities and to design genetically target drugs. Cell/Tissue technology and the nanorobot Artificial nanoscale building blocks may one day be utilised to help repair, sustain, or replacement of the body’s tissue and body parts. Uvocalise nanotechnology, researcher may be adept to make better artificial veins, arteries and heart valves; evolve a scaffold for growing patches of heart tissue to repair impairment from heart attacks; and grow artificial lung tissue. The use of simple carbon single-wall nanotube sheets to develop artificial muscle is in the soonest stages [16]. One of the more significant matters is that the foreign components might be strike by the body’s immune units, therefore means of reducing the risk of immune answer continues the major dispute for nanotechnology research in the area of tissue technology. Some researchers are attempting to assemble convoluted nanorobots that can journey throughout the human body utilising molecular engines and computers, shop and transport substances, perform procedures and communicate with physicians. Respirocytes, a spherical carbon nanorobot, is an demonstration that mimic the activity of the natural hemoglobin-filled red blood cells and is being revised [17]. However, despite the stride at which study is progressing and the exhilaration generated by the outlook of nanorobots, it could be numerous years before nanorobots are checked in humans. Conclusion Cancer is a worldwide problem. Nanocrystal plays an increasing role in battling cancer worldwide and in achieving the goal of eliminating suffering and death from cancer by 2015. Moreover, the use of multifactorial Nanocrystal in detecting and diagnosing carcinomas and sarcomas at earlier stages can be beneficial but needs further studies and investigation before implementing it in clinical practice. The general is for government to assume a main part, at the same time with the educated community and business relationship, in adding to the empowering foundation for perceiving and considering nanomaterial potential dangers, including (1) ID of delegate or structure nanomaterial, in connection to the structure, measurements, property and undertaking; (2) creating poisonous quality testing convention, covering inward breath, dermal, ingestion, and infusion presentation courses, for ID of full gimmick of the nanomaterial in connection to material property, the proposed use by the conceiv ably inclined, helpless patient and a definitive clinical applications; (3) strengthening the building methodologies under Good developing perform (GMP) for nanomedicine in particularly in the zone of creation, pontoons, taking care of and stockpiling to twofold watch that relentlessness and nature of the last stock is supported; (4) recognizing and administering the introduction level in working environment, air/waterborne discharges, people and different life forms and ecological media; and (5) surveying the impact of nanocyrstal items on the indigenous habitat as a proactive danger administration. Early theoretical and experimental studies of the biocompatibility of nanomaterials and sophisticated nanodevices have begun. References 1. Heidel, J. D., Davis, M. E. (2011). Clinical developments in nanotechnology for cancer therapy.Pharmaceutical research,28(2), 187-199. 2. Misra, R., Acharya, S., Sahoo, S. K. (2010). Cancer nanotechnology: application of nanotechnology in cancer therapy.Drug Discovery Today,15(19), 842-850. 3. Staples, M. P., Elwood, M., Burton, R. C., Williams, J. L., Marks, R., Giles, G. G. (2006). Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985.Med J Aust,184(1), 6-10. 4. Phan, J. H., Moffitt, R. A., Stokes, T. H., Liu, J., Young, A. N., Nie, S., Wang, M. D. (2009). Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment.Trends in biotechnology,27(6), 350-358. 5. Colin D. Medley, Joshua E. Smith, Zhiwen Tang, Yanrong Wu, Suwussa Bamrungsap, and Weihong Tan* (2008), Gold Nanoparticle-Based Colorimetric Assay for the Direct Detection of Cancerous Cells, Anal. Chem, 80, pp. 1067-1072 6. Chen et al., 2006 Z. Chen, H. Meng, G. Xing, C. Chen, Y. hao, G. Jia, T. Wang, H. Yuan, C. Ye, F. Zhao, Z. Chai, C. Zhu, X. Fang, B. Ma and L. Wan, Acute toxicological effects of copper nanoparticles in vivo, Toxicol. Lett. 163 (2006), pp. 109–120. 7. Bucolo et al., 2002 C. Bucolo, A. Maltese, G. Puglisi and R. Pignatello, Enhanced ocular anti-inflammatory activity of Ibuprofen carried by an Eudragit RS100 nanoparticle suspension, Ophthal. Res. 34 (2002), pp. 319–323. 8. Alexis, F., Rhee, J. W., Richie, J. P., Radovic-Moreno, A. F., Langer, R., Farokhzad, O. C. (2008). New frontiers in nanotechnology for cancer treatment. InUrologic Oncology: Seminars and Original Investigations(Vol. 26, No. 1, pp. 74-85). Elsevier. 9. Aliosmanoglu, A., Basaran, I. (2012). Nanotechnology in cancer treatment.J Nanomedicine Biotherapeutic Discov,2, 107. 10. Donaldson et al., 2004 K. Donaldson, V. Stone, C.L. Tran, W. Kreyling and P.J.A. Borm, Nanotoxicology, Occup. Environ. Med. 61 (2004), pp. 727–728. Full Text via CrossRef (144) 11. Ferrari, M. (2005). Cancer nanotechnology: opportunities and challenges.Nature Reviews Cancer,5(3), 161-171. 12. Barlow et al., 2005 P.G. Barlow, K. Donaldson, J. Maccallum, A. Clouter and V. Stone, Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration, Toxicol. Lett. 155 (2005), pp. 397–401. 13. Gmeiner, W. H., Ghosh, S. (2014). Nanotechnology for cancer treatment. Nanotechnology Reviews,3(2), 111-122. 14. Bulte, J.W, (2009), Nanoparticles in Biomedical Imaging: Emerging Technologies and Applications. New York, Springer, pp. 2. 15. Wang, X., Yang, L., Chen, Z. G., Shin, D. M. (2008). Application of nanotechnology in cancer therapy and imaging.CA: a cancer journal for clinicians,58(2), 97-110. 16. Gmeiner, W. H., Ghosh, S. (2014). Nanotechnology for cancer treatment. Nanotechnology Reviews,3(2), 111-122. 17. Bucolo et al., 2002 C. Bucolo, A. Maltese, G. Puglisi and R. Pignatello, Enhanced ocular anti-inflammatory activity of Ibuprofen carried by an Eudragit RS100 nanoparticle suspension, Ophthal. Res. 34 (2002), pp. 319–323.

Infancy Through Adolescence Essay

Changes in the home environment such as marital conflict, divorce and poor parenting can adversely affect family dynamics, and children especially, can develop both mental and physical health problems. Research finds a correlation between parental separation and the internalizing and externalizing problem behaviors in children; this includes childhood sleep problems due to marital conflict. Children can help define and influence the dynamics of marital conflict. Studies show that in early childhood, parent-child relationships are critical to a child’s healthy development especially the mother-child relations and maternal depression can cause poor parenting leading to emotional and behavioral problems. Child maltreatment is associated with alterations in stress physiology, increased risk for emotional and behavioral issues and increased risk for mental health issues in adolescence. Positive and supportive co-parenting can buffer against the negative effects of marital conflict and divorce especially in low-income and at-risk families. Successful co-parenting relationships can positively affect a child’s socio-emotional development and mental health. Family dynamics and changes in the home will affect the development and well-being of a child throughout infancy or adolescence. Home environments which are dysfunctional in nature, experiencing marital conflict, and separation/divorce or poor-parenting can cause problems within a child’s development including mental and physical issues. Some children will internalize their problems and suffer from anxiety and depression. Others will outwardly externalize their behaviors through aggression and conduct problems; preteens are especially at risk for antisocial behavior (Taylor, Purswell, Lindo, Jayne, & Fernando, 2011; Sentse, Ormel, Veenstra, Verhulst, & Oldehinkel, 2011). In the Barry & Kochanska (2011, p. 237) study, they point out that dysfunctional parenting, parental depressive symptoms and marital conflict are associated with childhood adjustment and development. Consistently, studies show that marital problems adversely affect child development and adjustment. As Rhoades, Leve, Harold, Neiderhiser, Shaw & Reiss (2011) state â€Å"the association between marital hostility and child adjustment is clearly established† and â€Å"pathways from marital hostility to child adjustment have been well studied, research[ed] to date† (p. 282). And Teti & Cole (2011) further add that â€Å"faulty parenting is frequently cited as a major causal factor in the development of child psychopathology† (p. 25). Emotions and Family Dynamics In Barry and Kochanska (2010) study, the authors look at family emotional well-being, the critical nature of the parent-child relationship and how this impacts a child’s development. Emotions are given and received through individuals and family relationships are shaped by them; family dynamics are influenced and develop from these relational emotions. The emotional affects are multi-dimension and reach all family members reciprocally. One approach known as transactional family dynamics looks at mutual influence processes between all family members (Schermerhorn, Chow & Cummings, 2010, p. 869). Although few studies have been conducted, the transactional family dynamic modal theorizes that if there are marital problems and conflict, the focus is not exclusively on the husband and wife’s problems, but how the family children also influence the marital relationship’s conflict. In one rare study, it was found that â€Å"in families with high levels of marital conflict, child externalizing problems predicted increases in marital conflict† (Schermerhorn et al. , 2010, p. 869); thus supporting the reciprocal nature in families. In support of other research, results from Schermerhorn, et al. (2010) study found that if a child is negative then it is associated with less marital positivity (p. 878). Within family subsystems, the marital relationship and the parent-child relationships are directly influenced by individual emotions and their interactions with one another. Some of these familial emotional interactions, reactions and feelings are healthy, but most are not when there is marital conflict; these unhealthy emotions create a variety of outcomes for a child’s development. Barry and Kochanska (2010) states, â€Å"In families, emotions profoundly influence mental health of the individuals, including sense of security, coping, personal growth, competence, adjustment, behavior problems, and psychopathology, including recovery and relapse† (p. 237). The emotional development, security and socialization of a child are directly related to the emotional exchange between the parent and child relationship; in fact, Barry and Kockanska (2010) find that it is a critical dimension especially during the early childhood years (p. 238). Since emotional healthiness is critical to healthy family relationships then unhealthy emotional states can be detrimental to a developing child causing attachment issues and possible psychopathology as they develop into adulthood. Parents’ emotional reactions to children’s emotions have important consequences for social and emotional development, including children’s psycho-physiological regulation, coping, emotional understanding, and friendship quality (Barry & Kockanska, 2010, p. 237). Home Environments and Child Development Some of the variables which cause changes in the family’s home environment and affect child development are marital conflict, divorce and poor parenting; these changes can be more negatively influential in lower-income environments. Family is one of the major components in human development; therefore, childhood development is greatly influenced by the health of the family unit and home environment. Studies have shown that marital conflict in the family will increase the risk of adjustment problems in children; additionally, marital conflicts can lead to negative parenting, such as inconsistent discipline or disengagement, putting the parent-child relationship at risk and further adding to the risk of child maladjustment (El-Sheikh & Whitson, 2006, p. 30; Peris, Goeke-Morey, Cummings, & Emery (2008), p. 633). Peris et al. 2008) finds that â€Å"marital conflict is linked to a host of ineffective parenting practices, ranging from the use of inconsistent discipline to diminished displays of warmth and responsivity in the parent-child relationship† (p. 633). Another area of concern in families with marital conflict is parentification of children in which the child takes on a parental role by providing emotional support for the parent; it is a reversed role where the child takes care of the parent. In the Peris et al. study, the authors look at how parentification responsibilities can be very stressful and taxing for a middle adolescent hich can cause, as previous research shows, shame, guilt, poor academic performance, increased adulthood depression and anxiety, and difficult peer relationships of which girls are at a greater risk than boys. (Peris et al. , p. 634). Peris et al. also points out that in childhood, parentification is associated with externalizing and internalizing behaviors, and poor social adjustment; additionally, poor parenting practice such as psychological control where a parent will use guilt to control their child’s behavior and maintain closeness will put children and adolescence at greater risk to maladjust ment and behavioral problems. Additional findings from Peris et al. study show that youth and their parents perceive the parentification dynamic differently. Youth perceive the relationship as low in warmth and support but the parent perceives it as warm and close; the study also concluded that the youth study group demonstrated internalizing and externalizing behaviors (p. 638) which is consistent with their hypothesis, other empirical studies and literature topics on parentification. Children from homes with higher levels of conflict have more adjustment problems than children from less conflictual homes especially with prolonged marital conflict (El-Sheikh & Whitson, 2006, p. 30). Marital conflict affects girls more than boys in which they have greater internalizing symptoms. El-Sheikh & Whitson (2006) explain that girls are subject to greater socialization pressures and communion especially during late childhood and adolescence; this socialization process is opposite of a boy who is pushed socially to be more independent. Girls may also be more emotionally involved in the marital arguments and boys avoid the conflict by claiming their independence (p. 37). Nonetheless, marital conflict has lasting affects for both boys and girls which affects childhood, adolescence and into adulthood. Social development is at risk in children who are from homes with marital conflict, divorce or poor parenting. Booth-LaForce & Oxford (2008) report that an unsupportive parental environment such as found in stressful environments like single-parent homes and/or low income can cause insensitive parenting which can lead to socially withdrawn behavior in children; (p. 299) many of these children who are socially withdrawn display â€Å"social-cognitive deficits and unskilled behavior, their self-perceptions are negative, they are more likely to be rejected and victimized by peers, and experience loneliness and depression† (p. 1298). Social learning theorists argue â€Å"that marital disruption may lead children to l earn angry, coercive, hostile, and even physically aggressive approaches to interpersonal problem solving† (Gattis, Simpson, & Christensen, 2008, p. 833). Another area of concern in childhood development within stressful home environments is the increase risk for stress-related physical illnesses. In a study by Fabricius & Luecken (2007) they report that â€Å"high family conflict, abuse, parental psychopathology, and divorce can serve to establish enduring dysregulations in the child’s physiological stress responses, promoting pathophysiology in the brain and body† (p. 195). Another area of concern is sleep deprivation. Marital conflict is related to disruption in a child’s sleep; sleep problems in children can be related to internalizing symptoms and externalizing behaviors. Additionally, children with sleep problems can also reciprocally influence the conflict between the parents. As Kelly & El-Sheikh (2011) point out â€Å"marital conflict and child sleep problems may be reciprocal and cyclical: exposure to marital conflict may lead to children’s sleep disruptions, which in turn may lead to increased marital conflict† (p. 413). Studies have also found that sleep problems in children can lead to aggressive behaviors (Kelly & El-Sheikh, 2011, p. 413). Separation, Post-Separation and Divorce Taylor, Purswell, Lindo, Jayne, & Fernando (2011) report that children from divorced families are at a higher risk for emotional and behavioral problems including antisocial behavior, disruptive conduct, delinquency, aggression, anxiety, depression, feelings of loneliness and abandonment, emotional maladjustment and academic problems (p. 124-125). A new family structure is stressful for all family members with each affecting the other. Higher levels of parental stress cause changes in the parent-child relationship putting it at risk. Lack of communication, conflict, hostility, stressors related to the divorce and the new family dynamics cause frustration and anger among the members. High rates of divorce continually influence the numerous studies conducted which look at their affects of divorce on childhood development. According to Sentse et al. (2011) â€Å"10-25% of children that experience a parental separation grow up to have more emotional and psychological problems† (p. 98). These problems can stem from the broken family, previous marital conflict, loss of support from family and friends, economic disadvantage and parenting problems. In the current study by Sentse et al. , the researchers found parental separation’s main affect on developing children was externalizing problems; although for some children the separation brought relief from all the marital conflicts. The study also found adolescences that were more temperamentally fearful had increased levels of internalizing behaviors; some of the side effects of the fearful individual who experiences parental separation include withdrawal, ignored by peers, anxious or depressive feelings – resulting in a cycle of negative symptoms which could result in mental health problems (p. 03). Depressive symptoms can stem from marital conflict and divorce; cyclically, marital conflict and divorce can cause depressive symptoms. Mothers are particularly prone to depressive symptoms and clinical depression during highly stressful events in their lives such as marital conflict, separation or divorce. Mothers who are depressed are likely to be less supportive and nurturing with their children and they are usually negative and critical which can lead to developmental problems such as internalizing and externalizing problems in their children (Connell, Hughes-Scalise, Klostermann & Azem, 2011, p. 53). Mothers with depression have â€Å"higher rates of irritability and aggression, which in turn may induce distress, anger and behavior problems in children† (Deboeck, Farris, Boker, & Borkowski, 2011, p. 1312). Deboeck et al. (2011) also finds that a mother’s psychosocial health can directly affect the development of a child; and, children of depressed mothers have difficulty regulating affect, have increased hyperactivity and attention deficits (p. 1313). Several studies have looked at maternal depressive symptoms and found a link between the mother’s criticizing, hostile parenting causing externalizing behaviors in adolescents; additionally, adolescents with depressed mothers were more likely to become depressed when they [adolescent] are faced with family conflict and discord (Allen & Manning, 2010, p. 833). Single motherhood is more stressful on both the mother and the children; single mothers are more likely to be depressed than married mothers. Compared to single mothers, married mothers have better mental health (Afifi, T. O. , Cox, B. J. & Enns, M. W. , 2006, p. 122). There are at least 9. 5 million families in American in which single mothers are head of the household (Afifi et al. 2006). Parenting stress is unusually high in single-mother homes and mothers have â€Å"greater financial difficulties, social isolation, and childcare responsibilities† compared to mothers who are married (Afifi et al. & Taylor, Purswell, Lindo, Jayne, & Fernando, 2011). Past research has found identified stressors which negatively affect the psychological well-being of single mothers; they are, low income, low education, family size, and ethnicity (Afifi et al. . 126). The results of Afifi et al. study found that psychiatric disorders in married mothers is lowest, with a slight increase in never married mothers, and the greatest increase was found in separated/divorced mothers; however, previous research found that women going through a separation or divorce had higher rates of poor mental health before the separation/divorce and after (Afifi et al. p. 127). Afifi et al. found that separated/divorced mothers had high levels of depression, dysthymia, GAD, alcohol abuse, PTSD, drug abuse, agoraphobia and antisocial personality disorder. Co-Parenting, Healthy Family Relationships, and Positive Outcomes Although marital conflict, separation/divorce, and poor parenting can adversely affect the home environment and negatively influence the development of children, there are positive factors which counter these adverse affects. Co-parenting is one of those factors. Co-parenting is associated with parents who mutually and cooperatively parent and raise their child together as a team. Although most of the research on co-parenting has been done on married couples and fathers, some does exist on co-parenting after the marital relationship has dissolved. Co-parenting can exist in families with marital conflict as part of a solution to positive parenting even in the midst of chaos and conflict. Positive co-parenting can buffer a child against the negative effects of marital conflict and divorce. There is increasing â€Å"evidence [which] indicates that successful co-parenting relationships are beneficial for children’s socio-emotional development† (Dush, Kotila, & Schoppe-Sullivan, 2011, p. 356). Other studies have found that co-parenting affects children positively by decreasing both internalizing and externalizing symptoms (Isacco, Garfield, & Rogers, 2010, p. 262). Healthy co-parenting relationships between separated or divorced couples can significantly improve the relationship between the non-residential father and the child; it could also help improve the relationship between the mother and father by reducing conflict. Many divorced fathers are less involved with their children and co-parenting because of the relational conflict with the divorced mother. Dush et al. (2011) states the key ingredients for co-parenting includes joint investment in the child, valuing the importance of each parent, respecting the other’s judgment, and ongoing, open communication (p. 357). A key factor for increasing healthy family relations and positive outcomes for children in families with marital conflict or divorce is active, supportive father involvement. As Dush et al. points out, â€Å"cooperative co-parenting relationships may be key to fostering positive nonresidential father involvement and lower levels of inter-parental conflict which have been linked to children’s behavioral outcomes, academic achievement, and psychological well-being† (p. 356). Another key component which fosters positive outcomes for children is father-child communication which has shown to decrease externalizing behaviors; (Afifi et al. 2006) additionally, open communication within the parent-child relationship where the child feels comfortable talking with their parents about the divorce has shown that children cope better (Taylor et al. , 2011). â€Å"A strong parent– child relationship can help ameliorate many of these [divorce] difficulties† (Taylor et al. 2011. p. 125). Family therapy is another positive component which can buffer the affects of marital conflict and divorce. Therapy can provide support for family members, teach problem-solving skills, communications training, conflict management and resolution.

Asthma Essay example - 1942 Words

Asthma / Grant 1 Asthma in a Fitness/School Setting For some, the agony of asthma may be an affliction only during childhood; for others, the illness persists throughout adulthood. The least fortunate are those who fall mortal victims. Asthma can kill. Medical science can offer only temporary relief at best. The deviousness of the disease defies almost all attempts at discovering a cure. Asthma can be mild; it can be devastating. Sometimes the symptoms disappear for many years but surface again with even greater severity. In an asthmatic attack the diameter of the small bronchi is diminished as a result of spasm of the muscular coat, active congestion of the mucous membrane and excessive secretion of tough mucus. In inspiration the†¦show more content†¦Although children with asthma often avoid physical activity for fear that it will trigger an asthma attack. Studies have shown that regular, moderate exercise can actually be helpful to children with asthma in addition to controlling weight problems. Lack of exercise can lead to physical de-conditioning as well as obesity, in turn, can cause asthma to worsen (quot;Amsterdam Newsquot;, 1998). For some asthma sufferers, a proper diet is more than a wishful goal, its a necessary step in leading a normal life. In addition to common triggers, food-triggers asthma affect in 6%-8% of asthmatic children but less than 2% of asthmatic adults. Often the triggers is sulfites, sulfite additives or a food allergen such as milk, eggs, peanuts, tree nuts, soy, wheat, fish or shellfish. Dr. Ron Simon of Scripps Clinic and Research Foundation in La Jolla, CA, stated, quot;sulfites in or added to food can cause potentially life-threatening reactions for asthmatics (quot;Medical Informationquot;, 1998).quot; Further research by Grant 3 Harvard Medical School have found that instead of being a by-product of asthma, extra pounds could make people more vulnerable to developing the disease (quot;Tufts Diet,quot; 1998). Even though physical activity has been found to be beneficial to asthmatics. Exercise-induced asthma have been prevalent in our society. AsShow MoreRelatedAsthma748 Words   |  3 PagesAs far as asthma goes, triggers for asthma are: allergies, family history (because there is a genetic influence) dust mites, pet dander, dust, cockroaches, pollen, mold, anything like that, pollutions and factory immetions can trigger some allergies. And often your patient will give you a history of GERD and exema (especially when they were a kid). In asthma we have reversible narrowing of the bronchioles. When they narrow they swell, so it gets hyper responsive, the airway tends to remodelRead MoreAsthma940 Words   |  4 PagesAsthma Describe the Disease: ​ Asthma is a chronic disease of the lungs that affects the airways and causes them to become very swollen and sensitive to the air that you breathe. With this disease you can get what is called an asthma attack, this is where your airways become narrower, making it difficult to breathe. You may notice that someone is having an asthma attack if the person begins wheezing, getting a tight chest/ chest pains, breathing problems, and coughing.  There are different typesRead MoreAsthma And Its Effects On Asthma1066 Words   |  5 Pageswho has been diagnosed with asthma. She has been having trouble controlling her asthma. Here is information on how she can understand asthma and control it and also help prevent asthma flare ups. Asthma is a chronic long term lung disease that inflames and narrows the airways. Asthma causes periods of wheezing, chest tightness, shortness of breath and coughing. Coughing usually occurs at night or early morning, can occur during the day if allergies flares your asthma. The airways are tubes that carryRead MoreAsthma Stepwise Management Of Asthma1272 Words   |  6 PagesAsthma Stepwise Management Asthma is a life-threatening inflammatory ailment of the upper airways that distresses approximately eight to ten percent of the populace, about seven million of the populace distressed with asthma are essentially the children (Arcangelo Peterson, 2013). Arcangelo and Peterson demarcate asthma as a chronic inflammatory ailment of the airways branded by airways blockage, inflammation, and hyper-responsiveness. The American Academy of Allergy and Immunology {AAAAI},Read MoreEffects Of Asthma On Children s Asthma954 Words   |  4 Pagesto other children in physical appearance, academics, athletics, and social interactions (Ball et al., 2015, p.208). The effects of asthma can play a direct role on how the child develops in these areas. Factors that affect asthma are being exposed to triggers and the medication management. The child is dependent on parents’ for initial management education of asthma treatment (Silva-Mendez Barros, 2013, p.1002). The parents’ beliefs a bout the adherence of medications have shown to have an influenceRead MoreAsthma2233 Words   |  9 Pages1. Discuss the pathophysiology of asthma. The pathophysiology of Asthma includes inflammation of the airway. The way in which this works is from an irritant which can include dust, pollen, cedar, or cat hair. When a reaction occurs, the airways become inflamed and narrow. The narrowing occurs because once the inflammatory response is triggered by an irritant, histamines, immunoglobulin E antibodies, and leukotrienes are released. Because of this, mucous production occurs. Since the bronchioles areRead MoreEssay on Asthma1127 Words   |  5 Pages Asthma is a disorder of the respiratory system in which the passages that enable air to pass into and out of the lungs periodically narrow, causing coughing, wheezing, and shortness of breath. This narrowing is typically temporary and reversible, but in severe attacks, asthma may result in death. Asthma most commonly refers to bronchial asthma, an inflammation of the airways, but the term is also used to refer to cardiac asthma, which develops when fluid builds up in the lungs as a complicationRead More Asthma Essay697 Words   |  3 Pages Asthma is a condition of the bronchial tubes characterized by episodes of constriction and increased mucous production. A person with asthma has bronchial tubes that are super sensitive to various stimuli, or triggers, that can produce asthma symptom.In other words, asthmatics have special sensitivity that causes their lung tissue to react far more than is should to various stimulating factors or triggers. For this reason, people with asthma are said to have quot;twitchy airways.quot;Some symptomsRead MorePathophysiology Of Chronic Asthma And Acute Asthma918 Words   |  4 Pagesdiseases of the respiratory system include; pneumonia, croup, asthma, bronchitis, laryngitis, and tuberculosis, affected disease location determines the signs and symptoms. Hereditary and environmental factors such as allergens and other irritants can be a contributory factor, especially in children. However, respiratory compromise occur as a re sult of incomplete airway development among this vulnerable population predisposing them to chronic asthma (Huether McCance, 2012). The purpose of this paper isRead MoreAsthma Essay1218 Words   |  5 PagesIntroduction Asthma is considered as one of the most common chronic and complex respiratory conditions which involve both environmental and genetic factors (1,2). It is such a condition of the airways presents as constriction of the bronchi and bronchioles in response to irritants. The vascular resistance of the pulmonary system will increase as constriction leads to a smaller vascular diameter (3,4). The prevalence of the disease is predicted to rise making it one of the major life-threatening

Shakespeare s Madness A Timeless Reflection Of Society

Shakespeare’s Madness: A Timeless Reflection of Society The word â€Å"madness† often provokes thoughts of schizophrenia, dementia, and psychosis; however, these illnesses prove not to be the exact cause of the various downfalls to the characters throughout the play Hamlet. The author, William Shakespeare, depicts a different type of insanity in the play, one that seems ambiguous but also feels eerily similar to ones that still affect others to this day. Shweta Bali, author of Mechanics of Madness in Hamlet, Macbeth, and King Lear, reiterates this by stating, â€Å"Insanity—real or obfuscated—is integral to the fiber of many of Shakespearean plays. Apart from reflecting the political turmoil, madness adds to the atmosphere of pathos, misfortune†¦show more content†¦Marrying the brother of her dead husband was not rational, further proving her mental instability. She knows that she is breaking her son, but mentally she is too lost to help her own son. Gertrude’s death was not directly at the fault of her insanity. Gertrude s death came from drinking poison, and it would not be a radical thought to say that this would have been prevented if she was have had the mental stability to take her son’s well being into consideration (V.ii.287). Although Gertrude’s madness is not always apparent throughout the play, the tragic downfall of Hamlet’s self proclaimed lover, Ophelia, was very intricate and her madness was extremely evident. Shakespeare illustrates the collapse of Ophelia in a much different way than any other character. Ophelia’s lunacy becomes apparent after the murder of her father, Polonius (III.iv.24). Her downfall was contributed to depression and confusion; however, Shakespeare often makes numerous biblical connections throughout her downfall, as if to raise the question if her madness was by the hand of God. Bali notices that Ophelia uses music and song to express her depression, and this is how Shakespeare connects her downfall to religion (85). Allison A. Chapman, author of Ophelia’s â€Å"Old Lauds†, explains that Ophelia makes the comment, â€Å"They say the owl was a baker’s daughter† (IV.v.42-43). Chapman continues on this by stating that this is oneSh ow MoreRelatedCommentary on William Shakespeare ´s As s You Like It and Gender Roles1376 Words   |  6 Pages Shakespeare’s society was strongly patriarchal .Women were expected to behave passively obediently and submissively toward their husbands ,who were considered the superior sex and were given the responsibility of governing the household .This is a topic undoubtedly critical to our understanding both of the role of women and the traditional concepts of gender and sexuality.Tarub explains that even domestic households were structured in accordance with patriarchal values ; the man ruled whilst